Selected Abstracts > Arrhythmia > Electrocardiographic factors playing a role in ischemic ventricular fibrillation in ST elevation myocardial infarction are related to the culprit artery

Title: Electrocardiographic factors playing a role in ischemic ventricular fibrillation in ST elevation myocardial infarction are related to the culprit artery

(Heart Rhythm 2008;5:71-78) © 2008 Heart Rhythm Society

BACKGROUND:
Sudden cardiac death caused by ischemic ventricular fibrillation (VF) associated with ST elevation myocardial infarction (STEMI) is one of the most frequent causes of death.

OBJECTIVE:

 We hypothesized that electrocardiographic (ECG) characteristics differ between STEMI patients with and without ischemic VF.

METHODS :
Fifty-five first STEMI patients with at least one 12-lead ECG recorded before ischemic VF were compared with 110 first STEMI patients without ischemic VF. Patients with bundle
branch blocks or high-degree atrioventricular blocks with escape rhythms were not included. ECG measurements were performed manually after scanning the ECG with the most prominent ST deviation into a software environment and magnifying it 4 times.

RESULTS :
Mean age was 57
12 years, and 126 patients were male. No differences were present between the VF and control group regarding baseline, enzymatic, and angiographic data. In
left circumflex artery and right coronary artery myocardial infarction,a longer QRS interval (109
23 ms vs. 91
16 ms, P  .02 and 107
24 ms vs. 93
19, P  .02) was present. In the latter the PR interval (211
64 ms vs. 160
36 ms, P .001) and ST deviation score (3.6
1.0 mV vs. 1.7
1.5 mV, P .001) were also increased. In the left anterior descending artery group no differences in conduction intervals and ST deviation score were present.

CONCLUSION :
Longer PR and QRS intervals in right coronary artery and left circumflex artery MI fit with the perfusion and activation pattern of the atrioventricular node and the ventricular myocardium. Myocardium perfused by the left anterior descending artery is activated earliest, hiding any intraventricular conduction delay within the QRS complex. Intramural slowed conduction could
be a substrate for ischemic VF.